Mary Tyler Moore died on Wednesday after battling Type I diabetes for nearly 50 years.
The iconic actressbest known for her 1970s sitcom The Mary Tyler Moore Showwas 80.
Stars were quick to react to the passing of the Hollywood icon. Longtime friend Larry King posted on twitter: '#MaryTylerMoore was a dear friend and a truly great person. A fighter. Rest in peace, MTM.'
A wonderful life: Mary Tyler Moore died on Wednesday at age 80 and stars were quick to react to the passing of the Hollywood icon
Pal: Longtime friend Larry King posted on twitter: '#MaryTylerMoore was a dear friend and a truly great person. A fighter. Rest in peace, MTM'
Andy Cohen of Watch What Happens Live added: 'RIP beautiful, upbeat, shining, glorious, wonderful, iconic Mary Tyler Moore.'
And Star Trek star George Takei said: 'She turned the world on with her smile.'
Michelle Rodriguez shared a photo of the star from the Mary Tyler Moore Show. The actress said, 'RIP to another legend.'
Fan: Andy Cohen of Watch What Happens Live added: 'RIP beautiful, upbeat, shining, glorious, wonderful, iconic Mary Tyler Moore'
Out of this world: And Star Trek star George Takei said: 'She turned the world on with her smile'
Another legend: Michelle Rodriguez shared a photo of the star from the Mary Tyler Moore Show
She already misses her: Selma Blair said: 'What an angel. Always was and will be. A great part of my childhood and so many people's lives'
Sad: Sandra Bernhard added: 'You're going to make it after all oh no please tell me it's not true'
Selma Blair said: 'What an angel. Always was and will be. A great part of my childhood and so many people's lives.'
Sandra Bernhard added: 'You're going to make it after all oh no please tell me it's not true.'
Her early years: The star with Dick Van Dyke for The Dick Van Dyke Show in 1961
Her rep said in a statement, 'Today, beloved icon, Mary Tyler Moore, passed away at the age of 80 in the company of friends and her loving husband of over 33 years, Dr. S. Robert Levine.
'A groundbreaking actress, producer, and passionate advocate for the Juvenile Diabetes Research Foundation, Mary will be remembered as a fearless visionary who turned the world on with her smile.'
Moore passed away at a Connecticut hospital with family members by her side.
She was diagnosed with diabetes when she was 33, early on during the run of her TV series, but the condition took a serious toll on her health in later years.
Moore had surgery to remove a benign brain tumor in 2011 and three years later it was reported that she was suffering from heart and kidney problems.
She was also said to be almost blind.
The beauty made her first big mark in the 1960s with The Dick Van Dyke Show.
British actor Stephen Fry paid tribute via Twitter as he was rehearsing his new sitcom The Great Outdoors on stage 2 at CBS Studios in Los Angeles where TMTM Show was filmed
British actor Stephen Fry was rehearsing his new sitcom The Great Outdoors on stage 2 at CBS Studios in Los Angeles when news of the legend's passing broke.
He posted on twitter out a photo of the plaque that memorializes the sound stage as the place where The Mary Tyler Moore Show was shot.
'A minute's silence as we remembered 1 of the true greats of TV comedy,' he wrote.
Daily Mail