Pedro, Willian and Eden Hazard start behind Diego Costa with Oscar on the bench, while Charlie Austin comes into the Saints' starting XI in place of Graziano Pelle
Chelsea are unchanged from their 5-1 FA Cup win over Manchester City as they take on Southampton in the Premier League.
Interim boss Guus Hiddink has selected a settled line-up for the third successive game, with the same group of players facing Paris Saint-Germain in the Champions League last week.
Captain John Terry is not named on the bench as the former England defender continues his recovery from injury.
Branislav Ivanovic partners Gary Cahill at centre-back, with Abdul Baba Rahman keeping his place at left-back.
January signing Charlie Austin starts up front alongside Shane Long for Southampton, with Graziano Pelle dropping to the bench.
Cedric Soares also comes into the starting XI as James Ward-Prowse is named as a substitute.
Southampton starting XI: Forster; Soares, Fonte, Van Dijk, Bertrand; Targett, Clasie, S.Davis, Romeu; Long, Austin.
Subs: Stekelenburg, Yoshida, Martina, Ward-Prowse, Mane, Tadic, Pelle.
Chelsea starting XI: Courtois; Azpilicueta, Cahill, Ivanovic, Baba Rahman; Mikel, Fabregas; Pedro, Willian, Hazard; Diego Costa.
Subs: Begovic, Matic, Loftus-Cheek, Kenedy, Oscar, Traore, Remy.
- Goal