United have made three changes from the side that lost to Liverpool on Thursday, while West Ham have named an attacking team with Andy Carroll starting up front
Louis van Gaal has kept faith with Marouane Fellaini for Manchester United's FA Cup sixth round clash with West Ham.
The Belgium was criticised by supporters for his performance in Thursday's Europa League defeat to Liverpool, but he is retained in the centre of midfield alongside Michael Carrick, who replaces Morgan Schneiderlin.
Further forward, Juan Mata and Memphis Depay drop out for Ander Herrera and Jesse Lingard, which means Marcus Rashford is handed a sixth consecutive start.
West Ham, meanwhile, have named an attacking side as they look to secure their place in the semi-final alongside Crystal Palace, Everton and Watford.
Andy Carroll starts up front, where he will be supported by Emmanuel Emenike, Manuel Lanzini and Dimitri Payet
Man Utd: De Gea; Varela, Smalling, Blind, Rojo; Carrick, Fellaini; Rashford, Herrera, Lingard; Martial.
Subs: Romero, Darmian, Williams, Schneiderlin, Schweinsteiger, Januzaj, Memphis.
West Ham: Randolph; Antonio, Reid, Ogbonna, Cresswell; Kouyate, Noble; Emenike, Lanzini, Payet; Carroll.
Subs: Adrian, O'Brien, Song, Obiang, Moses, Sakho, Valencia.
- Goal