It is fair to say that it attracted rather more reaction than the standard Europa League last 16 draw:
Louis van Gaal has played Liverpool four times since arriving at United in 2014 and has won all four games, most recently a 1-0 victory at Anfield. They defeated them 3-1 at Old Trafford earlier in the season thanks to a superb goal from Anthony Martial.
Elsewhere, Gary Neville's Valencia have been paired with another Spanish side, Athletic Bilbao.
Games will be played on 10th and 17th March.
What are the players saying?
"I was in the gym. I think everyone got the message. If you see all teams left in there aren't any easy games. They know us as good as we know them so it makes no difference. Last game we played at home we were better team. We have to stay calm. At this moment in time I don't think anyone is thinking about it." - Simon Mignolet, Liverpool goalkeeper
What are the odds?
Man Utd win the tie 8/11
Liverpool win the tie Evens
Tottenham win the tie 6/4
What is the full draw?
- Telegraph