The German and Chilean stars will begin the tie from the bench after the exertions of Saturday's north London derby, while Elneny continues in the middle
Arsenal have elected to rest Mesut Ozil and Alexis Sanchez for their FA Cup fifth-round replay against Hull City, with Alex Iwobi, Theo Walcott and Joel Campbell starting in support of Olivier Giroud.
The Gunners had to fight to seal a 2-2 draw against Tottenham in Saturday's north London derby.
And perhaps mindful of the effect the clash had on his team's fitness, Arsene Wenger chose to give his two creative lynchpins a rest for Tuesday's clash.
Mohamed Elneny, meanwhile, continues in the first-team after making his first start at White Hart Lane.
The ex-Basel midfielder gets the nod thanks to Francis Coquelin's suspension.
Hull City: Jakupovic; Bruce, Maguire, Davies, Odubajo; Elmohamady, Meyler, Huddlestone; Diame, Powell, Diomande.
Subs: Kuciak, Tymon, Robertson, Livermore, Taylor, Aluko, Hernandez.
Arsenal: Ospina; Chambers, Mertesacker, Gabriel, Gibbs; Flamini, Elneny; Walcott, Iwobi, Campbell; Giroud.
Subs: Macey, Monreal, Ramsey, Reine-Adelaide, Willock, Ozil, Alexis.
- Goal